This week we're talking about the effects that brain tumor treatments, such as radiation and chemotherapy, may have on one's oral health. We interviewed Dr. Cherry Estilo, an expert in dental oncology - a discipline devoted to the dental and oral care of cancer patients.
Dr. Estilo received her Doctor of Dental Medicine (DMD) at the University of Pennsylvania School of Dental Medicine, and is a dentist at Memorial Sloan-Kettering Cancer Center. She has a special interest and expertise in the dental and oral evaluation and treatment of children with cancer as well as patients with head and neck cancer.
How may chemotherapy and radiation affect oral health? What are the most common side effects that brain cancer survivors may experience?
Dr. Estilo: There are no oral side effects that are specific to brain cancer treatment. However, oral side effects are common in patients receiving chemotherapy and radiation therapy to the head and neck. In addition, effects of chemotherapy and radiation therapy are different in that chemotherapy has a systemic effect which means that it can affect any cell in the body whereas radiation therapy only affects the cells in its path. For example, a patient who receives radiation therapy to the leg or chest will not be expected to have any effects in the mouth associated with that treatment.
The mouth is at risk of side effects from chemotherapy and head and neck radiation therapy. The oral effects of these treatments may be a direct cause of the treatment or may result indirectly from the side effects of treatment. Radiation therapy can directly affect the salivary glands that can result in dry mouth. It can also directly damage the oral tissue by causing scarring.
Slow healing and infection are indirect complications of cancer treatments. Chemotherapy may reduce the number of white blood cells and weaken the patient’s immune system, thus making it easier for the patient to develop an infection.
Oral side effects can be acute or chronic. Acute problems are those that occur during treatment. These may include mouth sores. Chronic problems are those that continue or develop months or even years after treatment ends. Chronic oral problems include dry mouth, infections, and changes in taste. Long-term or lingering dry mouth is a particularly difficult condition in which patients are at increased risk for tooth decay and mouth infections.
Why is the mouth at risk for oral health side effects?
Dr. Estilo: The mouth contains hundreds of different bacteria. Chemotherapy and radiation therapy can alter saliva production and disrupt the lining of the mouth and tip the healthy balance of bacteria. These changes can lead to infections, mouth sores, and increased riskfor tooth decay.
The other reason is related to how chemotherapy and radiation therapy work. Chemotherapy and radiation therapy stop the growth of rapidly dividing cells such as cancer cells. Unfortunately, these treatments do not differentiate between normal cells and cancer cells. Normal rapidly dividing cells are affected as well. Examples of rapidly dividing cells are hair follicles, cells that line the inside of the mouth, and cells that line the inside of the intestines; these are affected. This is why chemotherapy treatment can cause side effects of hair loss, mouth ulcers, and intestinal upset.
Are children that have received chemotherapy and radiation to the head or neck at greater risk for oral health problems in the future? How does age at the time of treatment affect risk for developing oral health complications?
Dr. Estilo: Thanks to advances in treatments, there have been great improvements in the survival rates of many childhood cancers. More and more pediatric cancer patients are surviving their disease. Children treated with chemotherapy and head and neck therapy at a young age of less than 6 years of age are at high risk for dental problems. Examples of dental problems include missing adult teeth, weakening of the outer layer of the tooth (enamel), and short roots. The severity of effects is related to the age of the child at time of treatment, the intensity and duration of chemotherapy, and dose of radiation therapy.
What are some preventive measures that brain tumor survivors can take to protect their oral health? For instance, should they see a dentist more frequently than the general population? Is this any different at all compared to those that have not undergone cancer related treatments?
Dr. Estilo: Survivors who have lingering dry mouth, children treated at a young age and those with pre-existing dental conditions such as gum disease, should seek regular dental care more frequently, perhaps three times a year. Otherwise, they can see the dentist twice a year.
As I’ve mentioned, people with dry mouth are at high risk for tooth decay. For patients with dry mouth, I recommend that the use of high-fluoride content prescription toothpaste. Survivors of pediatric brain tumors can have numerous dental problems and many of them will require extensive dental treatment; this special group of patients should be followed quite closely for the rest of their lives.
For brain tumor patients that are undergoing cancer treatments, are there any products or
treatments that are recommended to maintain/preserve oral health?
Dr. Estilo: Patients with poor mouth care and poor dental health at the time of cancer treatment may have more frequent and severe oral side effects. While undergoing treatment, patients should continue and maintain good oral hygiene that includes brushing after every meal and flossing daily. Parents of young children should brush their children’s teeth and avoid a diet rich in sugar.
There is no drug available to prevent or treat mouth sores. Care of mouth sores focuses on cleaning the mouth and relieving the symptoms. Swishing ice chips in the mouth may lessen the painful symptom of mouth sores.
Also, is it important that brain tumor patients and survivors to see a dentist that has experience or specialty in treating patients with a cancer diagnosis?
Dr. Estilo: If the survivor has no major chronic problems, he or she can see a local general dentist. A survivor of childhood brain tumor who develops significant dental developmental problem(s) should be followed by a dental oncologic specialist, or at the very least, this patient’s local general dentist should work closely with a dental oncologic specialist.
What information should brain tumor survivors share about their medical history with their
dental provider? Also, what, if any medical records will they need to bring along?
Dr. Estilo: How old they were when they were treated; types of treatments they received; and also, if available, the name of the chemotherapy and the dose and site of radiation therapy.
As far as accessing dental care, for the under-insured, are there any charities or sliding scale services that provide oral health screenings and dental care to cancer survivors that you know of?
Dr. Estilo: Various U.S. government agencies and private organizations may offer financial assistance for cancer or other healthcare needs.
NBTS Patient Services: Dental care at reduced rates is often available at colleges and universities with dental school clinics and through dental hygiene education programs. Visit the
American Dental Association's website view a listing of accredited dental education programs in the United States.
You can also contact your state or local health department for a referral to a public health clinic in your area that offers dental care.
Click here to access your state’s contact information.
If you or a brain tumor survivor or family member looking for dental care resources, please contact the NBTS Patient Services team at
800.934.2873 or by email at
info@braintumor.org.
Where can brain tumor patients and families go for more information on late effects of treatment on oral health?
Dr. Estilo: A good resource is the National Cancer Institute at
www.cancer.gov or at
800.4.CANCER.
Is there anything else that you’d like to share on the topic?
Dr. Estilo: I’d like to emphasize the importance of optimizing oral health before, during, and after cancer treatment. Many of the effects of treatment can be minimized and even avoided with aggressive preventive measures. In most cases adult brain tumor survivors can be seen by their general dentist for routine care, unless they have lingering problems. Survivors of childhood brain tumors, especially those treated at a very young age, should be followed very closely by a dental specialist.